id: Pfam:PF10218
pfam_id: PF10218
name: SREBP regulating gene protein
short_name: SPRING1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10218
counters:
  proteins: 2163
  matches: 2190
  proteomes: 1532
  taxa: 4943
  structures: 2
  alphafold_models: 1856
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019352
description: SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and
  cholesterol metabolism. It modulates the proper localisation of SCAP (SREBP cleavage-activating protein)
  to the endoplasmic reticulum, thereby controlling the level of functional SCAP [[cite:PUB00094523]].