id: Pfam:PF10220
pfam_id: PF10220
name: Smg8_Smg9
short_name: Smg8_Smg9
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10220
counters:
  proteins: 2394
  matches: 3813
  proteomes: 1604
  taxa: 5105
  structures: 8
  alphafold_models: 1986
  domain_architectures: 58
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019354
description: Smg8 and Smg9 are two subunits of the Smg-1 complex. They suppress Smg-1 kinase activity
  in the isolated Smg-1 complex, and are involved in nonsense-mediated mRNA decay (NMD) in both mammals
  and nematodes [[cite:PUB00054170]].