id: Pfam:PF10221
pfam_id: PF10221
name: Cell cycle and development regulator Mat89Bb
short_name: Mat89Bb
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10221
counters:
  proteins: 2014
  matches: 2302
  proteomes: 1297
  taxa: 4173
  structures: 10
  alphafold_models: 1761
  domain_architectures: 32
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019355
description: This is entry represents the cell cycle regulator Mat89b (also known as protein asunder),
  which plays an evolutionarily conserved role as a crucial regulator of both cell cycle and development
  [[cite:PUB00052522],[cite:PUB00088536]]. It is a component of INT (Integrator) complex, being involved
  in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5 [[cite:PUB00090216]].
  Mat89Bb is also required for the correct dynein-dynactin perinuclear localization [[cite:PUB00097736]].
  Mat89Bb is a PNG kinase substrate, that is essential for S-M cycles of early Drosophila embryogenesis,
  Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.