id: Pfam:PF10223
pfam_id: PF10223
name: Menorin N-terminal domain
short_name: Menorin_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10223
counters:
  proteins: 2267
  matches: 2741
  proteomes: 1273
  taxa: 4141
  structures: 0
  alphafold_models: 1940
  domain_architectures: 42
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019356
description: This entyr includes proteins FAM151A and FAM151B, the mammalian homologues of C. elegans
  menorin which is involved in generation of neurons and regulation of dendrite extension [[cite:PUB00100987],[cite:PUB00100988]].
  FAM151B has been shown to be essential for retinal function [[cite:PUB00100987]]. Sequence analysis
  and the fact that these proteins have a TIM-barrel fold similar to that in phospholipase D and glycerophosphodiester
  phosphodiesterase (GDPD) families, indicate that they belong to PLC-like phosphodiesterase superfamily,
  although their substrates and function remain unknown. According to structure predictions, this domain
  is found at the N-terminal of menorin while in FAM151A is found twice and in FAM151B which is much shorter,
  it is the only domain present.