id: Pfam:PF10224
pfam_id: PF10224
name: Short coiled-coil protein
short_name: DUF2205
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10224
counters:
  proteins: 3242
  matches: 3243
  proteomes: 2499
  taxa: 6762
  structures: 1
  alphafold_models: 2825
  domain_architectures: 25
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019357
description: This entry represents a highly conserved 100 residue coiled-coil region which is found in
  short coiled-coil protein (SCOC) in human and UNC-69 in Caenorhabditis elegans. In human, SCOC is required
  for autophagosome formation during amino acid starvation. It forms a starvation-sensitive trimeric complex
  with UVRAG (UV radiation resistance associated gene) and FEZ1 and may regulate ULK1 and Beclin 1 complex
  activities [[cite:PUB00086016]]. In C. elegans, this small, evolutionarily conserved coiled-coil domain-containing
  protein, UNC-69, acts as a binding partner of UNC-76. Together they participate in a common genetic
  pathway necessary for axon extension and cooperate to regulate the size and position of synaptic vesicles
  in axons. Moreover, both proteins colocalize as puncta in neuronal processes and mutations in UNC-69
  preferentially disrupt membrane traffic within axons [[cite:PUB00109243]].