id: Pfam:PF10228
pfam_id: PF10228
name: Histone PARylation factor 1
short_name: HPF1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10228
counters:
  proteins: 1724
  matches: 1797
  proteomes: 1319
  taxa: 4217
  structures: 11
  alphafold_models: 1506
  domain_architectures: 42
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR064898
description: Histone PARylation factor 1 (HPF1, previously known as C4orf27) is a key regulator of ADP-ribosylation
  (ADPr) signaling in response to DNA damage. It forms a complex with PARP-1 (poly(ADP-ribose) polymerase
  1), creating a composite active site. HPF1 is essential for Ser-ADPr (ADPr on serine residues), which
  represents the major fraction of ADPr synthesised after DNA damage. This protein is organised into two
  tightly-associated domains connected via an elaborate linker, showing an alpha-beta structure [[cite:PUB00081458],[cite:PUB00101317],[cite:PUB00101318],[cite:PUB00101316]].