id: Pfam:PF10231
pfam_id: PF10231
name: Cytochrome c oxidase assembly factor 8
short_name: COA8
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10231
counters:
  proteins: 1836
  matches: 1842
  proteomes: 1499
  taxa: 4636
  structures: 0
  alphafold_models: 1633
  domain_architectures: 41
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018796
description: Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously
  thought to induce apoptosis through the Cyclophilin-D-dependent pathway [[cite:PUB00086677]], is required
  for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome
  system (UPS) [[cite:PUB00093669]]. In Drosophila melanogaster, Apop1 is also involved in neurological
  impairment, COX enzymatic activity, and resistance to oxidative stress conditions [[cite:PUB00093671]].