id: Pfam:PF10240
pfam_id: PF10240
name: MABP domain
short_name: MABP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10240
counters:
  proteins: 5658
  matches: 5672
  proteomes: 1228
  taxa: 4000
  structures: 2
  alphafold_models: 1252
  domain_architectures: 65
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR023341
description: This domain is found in the N-terminal region of MVB12 proteins, which are subunits of the
  ESCRT-I complex involved in multivesicular body formation. The MABP domain adopts a type-I beta-prism
  fold with internal three-fold symmetry, consisting of three homologous segments each forming a three-stranded
  beta-sheet. It is found in diverse proteins including vertebrate DENND4A/B/C, Drosophila Crag, and bacterial
  MACPF-like proteins. The domain is believed to function as a membrane-associated adaptor that links
  other domains to vesicular membranes during intracellular trafficking. Most eukaryotic versions contain
  conserved cysteine residues in the first and third subdomains [[cite:PUB00045017],[cite:PUB00054220]].