id: Pfam:PF10265
pfam_id: PF10265
name: Mitoguardin
short_name: Miga
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10265
counters:
  proteins: 2970
  matches: 3183
  proteomes: 1243
  taxa: 4033
  structures: 3
  alphafold_models: 2653
  domain_architectures: 36
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019392
description: Mitoguardin (Miga) was first identified in flies as a mitochondrial outer-membrane protein
  that promotes mitochondrial fusion. Later, the mammalian Miga homologues, Miga1 and Miga2, were identified.
  They are found to promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via
  MitoPLD [[cite:PUB00077967],[cite:PUB00077968]].