id: Pfam:PF10282
pfam_id: PF10282
name: Lactonase, 7-bladed beta-propeller
short_name: Lactonase
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10282
counters:
  proteins: 20552
  matches: 22059
  proteomes: 10997
  taxa: 16490
  structures: 10
  alphafold_models: 13530
  domain_architectures: 523
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019405
description: This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type ([ec:3.1.1.31])
  which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate
  lactonising enzyme carboxy-cis,cis-muconate cyclase ([ec:5.5.1.5]) and muconate cycloisomerase ([ec:5.5.1.1]),
  which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate
  pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold [[cite:PUB00037024]].