id: Pfam:PF10300
pfam_id: PF10300
name: Iml2/Tetratricopeptide repeat protein 39
short_name: Iml2-TPR_39
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10300
counters:
  proteins: 9006
  matches: 9867
  proteomes: 2835
  taxa: 7559
  structures: 0
  alphafold_models: 7859
  domain_architectures: 143
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019412
description: This is a family of proteins conserved from fungi to humans, including fungal Inclusion body
  clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some
  uncharacterised proteins. Members of this family carry a tetratricopeptide repeat [pfam:PF07719] at
  their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localises
  to the cytoplasm and nucleus [[cite:PUB00016470]], and its expression is increased in response to DNA
  replication stress [[cite:PUB00066967]]. It is found to be involved in lipid droplet-mediated inclusion
  body clearing after protein folding stress [[cite:PUB00088292]]. In humans, TTC39A (also known as DEME6)
  is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic
  RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated
  with oestrogen receptor, but is not necessarily oestradiol-responsive [[cite:PUB00044224]]. TTC39B has
  been linked to lipid metabolism [[cite:PUB00072592]].