id: Pfam:PF10302
pfam_id: PF10302
name: DSC E3 ubiquitin ligase complex subunit 3, ubiquitin-like domain
short_name: Dsc3_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10302
counters:
  proteins: 1382
  matches: 1403
  proteomes: 1314
  taxa: 2795
  structures: 0
  alphafold_models: 1159
  domain_architectures: 26
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019413
description: This is the N-terminal ubiquitin-like domain of DSC E3 ubiquitin ligase complex subunit 3
  (Dsc3). Dsc3 is a component of the DSC E3 ubiquitin ligase complex (a Golgi-specific protein ubiquitination
  system) that functions in protein homeostasis under non-stress conditions, playing a role in protein
  quality control through endosome and Golgi-associated degradation pathway (EGAD) [[cite:PUB00098312],[cite:PUB00098082],[cite:PUB00098314]].
  Yeast DSC E3 ubiquitin ligase complex is the homologue of Hrd1 E3 ligase complex from mammals, in which
  Dsc1, Dsc2 and Dsc3 corresponds to Hrd1, Der1 and Usa1, respectively. Dsc3 is a Herp-like protein that
  acts as a bridge between Dsc1 and Dsc2 for their interaction [[cite:PUB00075404]].