id: Pfam:PF10343
pfam_id: PF10343
name: Queuosine salvage protein
short_name: Q_salvage
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10343
counters:
  proteins: 4001
  matches: 4166
  proteomes: 3056
  taxa: 8340
  structures: 8
  alphafold_models: 3415
  domain_architectures: 74
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019438
description: Queuosine salvage proteins occur in most Eukarya as well as in a few bacteria possible via
  horizontal gene-transfer. Queuosine (Q) is a chemical modification found at the wobble position of tRNAs
  that have GUN anticodons, and it ensures faithful translation of the respective C- and U-ending codons.
  Most bacteria synthesize queuosine de novo, whereas eukaryotes rely solely on salvaging this essential
  component from the environment or the gut flora. This entry represents queuosine salvage proteins (Qng1,
  also known as DUF2419) which have been identified as a queuosine nucleoside glycosylases that play an
  essential role in allowing eukaryotic cells to salvage Q from bacterial sources and to recycle Q from
  endogenous tRNAs [[cite:PUB00075552],[cite:PUB00101386]].