id: Pfam:PF10344
pfam_id: PF10344
name: Hobbit/FMP27/BTLP2 family
short_name: Hobbit
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10344
counters:
  proteins: 4971
  matches: 6616
  proteomes: 2947
  taxa: 7811
  structures: 0
  alphafold_models: 835
  domain_architectures: 118
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045167
description: This entry represents the Hobbit protein from Drosophila melanogaster and its homologues
  such as the mitochondrial FMP27 protein from yeast (also known as Hob1) and BLTP2 (also known as KIAA0100)
  from human. These proteins are localized to endoplasmic reticulum-plasma membrane (ER-PM) contact sites
  described as conserved lipid-binding proteins. They are tube-forming transport proteins which bind to
  phosphatidylinositols and affect phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution
  [[cite:PUB00101862],[cite:PUB00101860],[cite:PUB00101861]]. They belong to the repeating beta-groove
  (RBG) superfamily together with VPS13, ATG2, SHIP164, Csf1/BLTP1 proteins, which are all conserved lipid
  transfer proteins containing long hydrophobic grooves [[cite:PUB00101860],[cite:PUB00101861]]. They
  all share the same structure consisting of multiple repeating modules comprising five beta-sheets followed
  by a loop.