id: Pfam:PF10350
pfam_id: PF10350
name: THADA/TRM732, DUF2428
short_name: DUF2428
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10350
counters:
  proteins: 4556
  matches: 4613
  proteomes: 3000
  taxa: 7989
  structures: 1
  alphafold_models: 662
  domain_architectures: 87
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019442
description: 'This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast
  homologue, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2''- O-methylate tRNA residue
  32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homologue
  FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked
  intellectual disability [[cite:PUB00098320],[cite:PUB00098321],[cite:PUB00098322]]. It has been suggested
  that these proteins may play a role in additional biological processes not related to translation. This
  domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al.,
  Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962) [[cite:PUB00098320],[cite:PUB00098321],[cite:PUB00098322]].'