id: Pfam:PF10354
pfam_id: PF10354
name: rRNA (uridine-N3-)-methyltransferase BTM5-like
short_name: BMT5-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10354
counters:
  proteins: 5700
  matches: 6225
  proteomes: 3040
  taxa: 7802
  structures: 0
  alphafold_models: 4666
  domain_architectures: 206
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019446
description: This is the N-terminal domain found in proteins from plants, yeast and humans, including
  25S rRNA (uridine-N(3))-methyltransferase BMT5 from S. cerevisiae and the poorly characterised Ferredoxin-fold
  anticodon-binding domain-containing protein 1 from human and Heavy metal-associated isoprenylated plant
  protein 41 from Arabidopsis. This domain has a characteristic Rossmann-like fold of S-adenosyl-L-methionine
  (SAM) binding domains [[cite:PUB00075659]]. BTM5 is a SAM-dependent methyltransferase that specifically
  methylates the N3 position of uridine in 25S rRNA.