id: Pfam:PF10382
pfam_id: PF10382
name: DNA helicase ZGRF1-like, N-terminal domain
short_name: ZGRF1-like_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10382
counters:
  proteins: 2701
  matches: 3579
  proteomes: 2096
  taxa: 5362
  structures: 0
  alphafold_models: 1903
  domain_architectures: 60
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018838
description: This domain can be found in human 5'-3' DNA helicase ZGRF1 and similar eukaryotic proteins.
  ZGRF1 promotes repair of replication -blocking DNA lesions through stimulation of homologous recombination
  (HR) [[cite:PUB00098331],[cite:PUB00153163]]. This domain can also be found in Mte1 (Mph1-associated
  telomere maintenance protein 1) from Saccharomyces cerevisiae, which is involved in telomere maintenance
  [[cite:PUB00044234]] and in and fission yeast Dbl2, involved in meiotic chromosome segregation. However,
  there is no evidence to suggest that this domain, which is predicted to adopt an all-beta structure,
  is implicated in DNA damage resistance or nuclear focus formation [[cite:PUB00044235],[cite:PUB00089971],[cite:PUB00101196],[cite:PUB00101195]].