id: Pfam:PF10444
pfam_id: PF10444
name: Nbl1 / Borealin N terminal
short_name: Nbl1_Borealin_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10444
counters:
  proteins: 2589
  matches: 2591
  proteomes: 2074
  taxa: 5378
  structures: 13
  alphafold_models: 2226
  domain_architectures: 20
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018851
description: Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates
  mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p,
  INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1)
  is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast
  to be essential for viability, and for CPC localisation, stability, integrity, and function [[cite:PUB00053916]].
  The N terminus of Borealin is homologous to Nbl1 [[cite:PUB00053916]]. This family contains both Nbl1,
  and the N terminal region of Borealin.