id: Pfam:PF10474
pfam_id: PF10474
name: Syndetin, C-terminal
short_name: Syndetin_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10474
counters:
  proteins: 3084
  matches: 3139
  proteomes: 1737
  taxa: 5463
  structures: 0
  alphafold_models: 2621
  domain_architectures: 43
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019514
description: The function of this domain is unknown but it is found at the C terminus of syndetin (VPS50),
  a unique component of the endosome-associated retrograde protein (EARP) complex. The EARP complex otherwise
  shares four of its five subunits with the Golgi-associated retrograde protein (GARP) complex. The EARP
  complex is localised to recycling to endosomes where it acts as a tethering complex for recycling of
  plasma membrane receptors [[cite:PUB00077150]].