id: Pfam:PF10475
pfam_id: PF10475
name: Vacuolar-sorting protein 54, of GARP complex
short_name: Vps54_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10475
counters:
  proteins: 5144
  matches: 5274
  proteomes: 2258
  taxa: 6739
  structures: 0
  alphafold_models: 4342
  domain_architectures: 75
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019515
description: This is a family of vacuolar-sorting proteins 54, from eukaryotes. Along with VPS52 and VPS53
  this forms the Golgi-associated retrograde protein complex GARP [[cite:PUB00090044]]. VPS54 is separated
  into N- and C-terminal regions each of which has a different function. This N-terminal family of is
  important for GARP complex assembly and stability, whereas the C-terminal domain, [pfam:PF07928], brings
  about localisation to an early endocytic compartment [[cite:PUB00109230]].