id: Pfam:PF10486
pfam_id: PF10486
name: Phosphoinositide 3-kinase gamma adapter protein p101 subunit
short_name: PI3K_1B_p101
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10486
counters:
  proteins: 2599
  matches: 4190
  proteomes: 771
  taxa: 2403
  structures: 8
  alphafold_models: 2260
  domain_architectures: 16
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019522
description: Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular
  signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled
  receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits [[cite:PUB00044437]].