id: Pfam:PF10521
pfam_id: PF10521
name: Tti2 family
short_name: Tti2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10521
counters:
  proteins: 2074
  matches: 2084
  proteomes: 1836
  taxa: 4720
  structures: 2
  alphafold_models: 1736
  domain_architectures: 38
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018870
description: This family includes budding yeast Tel2-interacting protein 2 (Tti2) and similar proteins
  from animals and fungi. Tti2 is a component of the tel2-tti1-tti2 (TTT) complex, which is involved in
  the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin
  C (MMC). Its homologue from humans, together with the TTT complex and HSP90, may participate in the
  proper folding of newly synthesised phosphatidylinositol 3-kinase-related protein kinase (PIKK) proteins
  [[cite:PUB00075571],[cite:PUB00073582],[cite:PUB00151832],[cite:PUB00088257]].