id: Pfam:PF10577
pfam_id: PF10577
name: FAM171A1/A2/B, N-terminal
short_name: FAM171A1-2-B_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10577
counters:
  proteins: 2670
  matches: 2751
  proteomes: 780
  taxa: 2365
  structures: 0
  alphafold_models: 2305
  domain_architectures: 48
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR048530
description: This a domain found at the N-terminal of a family of proteins that includes FAM171A1/A2 and
  FAM171B. FAM171A1 is a type 1 transmembrane glycoprotein also known as astroprincin (APCN) due to abundant
  expression in astrocytes. APCN is also expressed in placental trophoblasts, skeletal and heart muscle,
  kidney and pancreas [[cite:PUB00100164]]. APCN is involved in the regulation of the cytoskeletal dynamics,
  playing a role in actin stress fiber formation.