id: Pfam:PF10709
pfam_id: PF10709
name: Protein YebY
short_name: YebY
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10709
counters:
  proteins: 647
  matches: 649
  proteomes: 626
  taxa: 1011
  structures: 3
  alphafold_models: 385
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019648
description: This protein family includes Protein YebY from Escherichia coli and similar proteins predominantly
  found in Gammaproteobacteria. YebY is a component of the AZY copper uptake system, where it functions
  as a negative regulator of the copper importer YebZ [[cite:PUB00163268]]. At high copper concentrations,
  YebY may act as a safety valve, preventing toxic copper overload by inhibiting the import activity of
  YebZ and YobA [[cite:PUB00163268]]. The reduced form of YebY binds Cu(+) and Cu(2+) with low affinity
  and shows low specificity, also binding Co(2+), Ni(2+), and Ag(+) [[cite:PUB00100157]]. However, the
  low affinity of copper binding, together with the stabilisation imparted by a disulphide bond, suggests
  that this metal binding is likely not physiologically relevant [[cite:PUB00100157]].