id: Pfam:PF10747
pfam_id: PF10747
name: Sporulation inhibitor of replication protein SirA
short_name: SirA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10747
counters:
  proteins: 605
  matches: 606
  proteomes: 603
  taxa: 764
  structures: 1
  alphafold_models: 360
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019683
description: This entry represents the Sporulation inhibitor of replication (sirA) family of proteins
  from Bacillus sp. Induction of sporulation in rapidly growing cells inhibits replication; this is thought
  to be through the action of SirA protein and independent of phosphorylated Spo0A; however SirA protein
  synthesis is induced by Spo0A [[cite:PUB00054159]].