id: Pfam:PF10806
pfam_id: PF10806
name: SAM35, subunit of SAM coomplex
short_name: SAM35
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10806
counters:
  proteins: 408
  matches: 408
  proteomes: 401
  taxa: 815
  structures: 6
  alphafold_models: 349
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021211
description: SAM35 is a family of fungal proteins found in the peripheral mitochondrial outer membrane.
  It is essential for cell viability. It forms a subunit of the SAM (sorting and assembly machinery) complex
  and is crucial for the assembly of the precursors of Tom40 and porin, the outer membrane beta-barrel
  proteins involved in mitochondrial biogenesis [[cite:PUB00074955],[cite:PUB00016442]]. SAM35 is required
  in order for the Sam50 subunit of the SAM complex to bind outer membrane substrate proteins [[cite:PUB00110449]].