id: Pfam:PF10818
pfam_id: PF10818
name: secA translation cis-regulator SecM, small type
short_name: SecM_small
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10818
counters:
  proteins: 100
  matches: 100
  proteomes: 100
  taxa: 162
  structures: 0
  alphafold_models: 70
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR020508
description: In E. coli, SecM encodes a presecretory protein that regulates secA expression at the translational
  level. SecM contains a C-terminal sequence motif that induces a transient translation arrest [[cite:PUB00097606]].
  SecM signal peptide plays an essential role in this regulatory process by acting as a molecular timer
  that coordinates secM membrane targeting with the synthesis of the arrest motif [[cite:PUB00097606]].