id: Pfam:PF10862
pfam_id: PF10862
name: FcoT-like thioesterase domain
short_name: FcoT
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10862
counters:
  proteins: 298
  matches: 298
  proteomes: 264
  taxa: 450
  structures: 4
  alphafold_models: 186
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022598
description: Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown
  function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis [[cite:PUB00048671]] suggested
  a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long
  chain fatty acyl groups [[cite:PUB00048671]]. The maximal Kcat was observed for palmitoyl-CoA although
  longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.