id: Pfam:PF10902
pfam_id: PF10902
name: WYL_2, Sm-like SH3 beta-barrel fold
short_name: WYL_2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10902
counters:
  proteins: 390
  matches: 395
  proteomes: 329
  taxa: 740
  structures: 0
  alphafold_models: 139
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024401
description: WYL_2 is a family of Sm-like SH3 beta-barrel fold containing domains. WYL is named for three
  conserved amino acids found in a subset of domains of this superfamily. These residues are not strongly
  conserved throughout the family. Rather, the conservation pattern includes four basic residues and a
  position often occupied by a cysteine [[cite:PUB00085051]], which are predicted to line a ligand-binding
  groove typical of the Sm-like SH3 beta-barrels. It is predicted to be a ligand-sensing domain that could
  bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas
  and other defense systems such as the abortive infection AbiG system [[cite:PUB00085051]]