id: Pfam:PF10922
pfam_id: PF10922
name: Bacteriophage T7-like, gene 1.2
short_name: T7-like_gp12
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10922
counters:
  proteins: 154
  matches: 154
  proteomes: 147
  taxa: 353
  structures: 4
  alphafold_models: 5
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR020147
description: This entry represents the bacteriophage T7 Gp1.2 protein, a small protein that inhibits the
  Escherichia coli dGTPase (Dgt). Dgt hydrolyzes dGTP to deoxyguanosine and triphosphate, which can limit
  T7 phage replication by restricting the available dGTP pool. Gp1.2 binds to Dgt and prevents dGTP hydrolysis,
  preserving the nucleotide pool necessary for phage DNA replication. The protein adopts a barrel-shaped
  fold with a three-stranded antiparallel beta sheet covered on one side by two parallel alpha helices.
  The N-terminus of Gp1.2 inserts into the active site of Dgt, trapping the active site in a non-catalytic
  conformation.