id: Pfam:PF10937
pfam_id: PF10937
name: Alpha-ketoglutarate dehydrogenase component 4/YMR-31
short_name: Kgd4-YMR31
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10937
counters:
  proteins: 1927
  matches: 1958
  proteomes: 1742
  taxa: 4549
  structures: 0
  alphafold_models: 1635
  domain_architectures: 23
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR020373
description: This entry represents the alpha-ketoglutarate dehydrogenase component 4 (Kgd4, also referred
  to as Ymr31/MRPS36) which was originally identified as a subunit of the mitochondrial ribosome [[cite:PUB00056057],[cite:PUB00012961],[cite:PUB00010175]].
  Through biochemical studies, it was shown that this protein co purifies with the oxoglutarate dehydrogenase
  complex (OGDC). Both mitochondrial ribosome 28S subunit and OGDC have a similar size and OGDC is highly
  abundant, being found to contaminate ribosomal preparations [[cite:PUB00089008]]. Kgd4 plays an evolutionarily
  conserved role in the organisation of mitochondrial alpha-KGDH complexes of fungi and animals which
  constitutes a molecular adaptor that is necessary to form a stable alpha-KGDH enzyme complex [[cite:PUB00089008],[cite:PUB00100356]].