id: Pfam:PF10940
pfam_id: PF10940
name: Leader peptide SpeFL
short_name: SpeFL
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10940
counters:
  proteins: 119
  matches: 119
  proteomes: 116
  taxa: 193
  structures: 0
  alphafold_models: 62
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021237
description: SpeFL is a small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase
  gene (speF) that controls expression of downstream genes (speF and patE) by nascent chain-translational
  arrest and transcriptional attenuation. Ornithine capture by a translating ribosome controls bacterial
  polyamine synthesis, inducing the expression of ornithine decarboxylase SpeF4, in a mechanism involving
  ribosome stalling and transcription antitermination [[cite:PUB00098030]]