id: Pfam:PF10960
pfam_id: PF10960
name: BhlA holin family
short_name: Holin_BhlA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10960
counters:
  proteins: 464
  matches: 465
  proteomes: 329
  taxa: 625
  structures: 0
  alphafold_models: 280
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024405
description: 'The Phage_holin_BhlA family is a family of holin-like proteins from both bacteriophages
  and bacterial chromosomes. In bacteriophage, holins are small membrane proteins that accumulate and
  oligomerise to form non-specific lesions in the cytoplasmic membrane allowing the release of the second
  protein, endolysins, to access the peptidoglycan [[cite:PUB00110260]]. Most holins share common structural
  features: two or three transmembrane domains separated by a beta-turn, a short hydrophilic N-terminus,
  a highly charged C-terminus and a dual translational start motif. The BhlA holin of Bacillus is found
  to be toxic to the host cell where the site of action of is on the cell membrane and causes bacterial
  death by cell membrane disruption [[cite:PUB00110261]].'