id: Pfam:PF10986
pfam_id: PF10986
name: ZrgA family zinc uptake protein
short_name: ZrgA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10986
counters:
  proteins: 1443
  matches: 1522
  proteomes: 1386
  taxa: 2045
  structures: 6
  alphafold_models: 869
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021253
description: This entry represents the ZrgA family of zinc uptake proteins. ZrgA plays a predominant role
  in zinc acquisition in Vibrio parahaemolyticus and other members of the Vibrionaceae family. The protein
  is part of the ZrgABCDE system that functions as a zinc transporter [[cite:PUB00159002]]. ZrgA expression
  is negatively regulated by the zinc uptake regulator (Zur) and is derepressed under zinc limitation
  conditions. The gene is part of an operon that includes zrgB (ABC transporter permease), zrgC (ABC transporter
  ATP-binding protein), zrgD and zrgE. The ZrgA protein contains several conserved motifs potentially
  involved in zinc binding. The wild type ZrgA can bind up to 10 zinc ions with four high-affinity zinc
  binding sites [[cite:PUB00159005]]. The structures of ZrgA from Vibrio cholerae and its homologue, protein
  PA4063 from Pseudomonas aeruginosa, were determined bound to zinc [[cite:PUB00159005],[cite:PUB00159006]].
  These proteins adopt an alpha/beta structure consisting of a six-stranded meander beta-sheet and two
  alpha-helices packed on it with an unique topology.