id: Pfam:PF10988
pfam_id: PF10988
name: Putative auto-transporter adhesin, head GIN domain
short_name: DUF2807
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10988
counters:
  proteins: 10865
  matches: 11258
  proteomes: 3662
  taxa: 5354
  structures: 14
  alphafold_models: 7045
  domain_architectures: 34
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021255
description: This bacterial family of proteins shows structural similarity to other pectin lyase families.
  Although structures from this family align with acetyl-transferases, there is no conservation of catalytic
  residues found. It is likely that the function is one of cell-adhesion. In PDB:3jx8, it is interesting
  to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs
  defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in
  the C-terminal half of the protein, which could be grouped into 4 repeats of two. It seems likely that
  this family belongs to the superfamily of trimeric auto-transporter adhesins (TAAs), which are important
  virulence factors in Gram-negative pathogens [[cite:PUB00029784]] [[cite:PUB00051306]]. In the case
  of Parabacteroides distasonis, which is a component of the normal distal human gut microbiota, TAA-like
  complexes probably modulate adherence to the host (information derived from TOPSAN).