id: Pfam:PF10995
pfam_id: PF10995
name: Cellulose biosynthesis protein BcsE, N-terminal domain
short_name: BcsE_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10995
counters:
  proteins: 604
  matches: 605
  proteomes: 594
  taxa: 869
  structures: 4
  alphafold_models: 326
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR063588
description: This entry includes members involved in cellulose biosynthesis such as BcsE proteins found
  in Salmonella typhimurium. They consist of a N-terminal NTPase catalytically incompetent nucleoside
  triphosphatase domain followed by a REC (phosphorylation-incompetent receiver domain) and a C-terminal
  GGDEF (degenerate diguanylate cyclase domain). The REC and GGDEF domains were firstly described as the
  GIL domain [[cite:PUB00100649],[cite:PUB00163548]]. BcsE proteins are not essential for cellulose synthesis
  but is critical for maximal cellulose production. Cellulose production in enterobacteria is controlled
  by a two-tiered c-di-GMP-dependent system involving BcsE and the PilZ domain containing glycosyltransferase
  BcsA [[cite:PUB00086880],[cite:PUB00075887],[cite:PUB00100649],[cite:PUB00100650],[cite:PUB00100648]].
  This domain forms a membrane-proximal head-to-head dimer of P-loop nucleotide NTPase-like modules [[cite:PUB00163548]].