id: Pfam:PF11001
pfam_id: PF11001
name: YDR124W-like, helical bundle domain
short_name: AFUB_07903_YDR124W_hel
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11001
counters:
  proteins: 1718
  matches: 1722
  proteomes: 1067
  taxa: 2117
  structures: 0
  alphafold_models: 1429
  domain_architectures: 26
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR047092
description: This entry represents mitochondrial proteins from fungi, such as subtelomeric hrmA-associated
  cluster protein AFUB_079030 from Aspergillus fumigatus and YDR124W from yeast. Null mutant showed severe
  fragmentation of mitochondria and its expression is strongly induced by alpha factor. These proteins
  may have a role in maintenance of mitochondrial morphology [[cite:PUB00101836]]. This entry represents
  an helical bundle domain which seems to adopt a similar arrangement than the EIN3-like DNA-binding domain
  (Based on structural comparison, DALI server). AFUB_079030 is part of the subtelomeric hrmA-associated
  cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased
  beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting
  in a loss of vertically aligned polarised growing filaments [[cite:PUB00153731]].