id: Pfam:PF11009
pfam_id: PF11009
name: Monothiol bacilliredoxin BrxC
short_name: BrxC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11009
counters:
  proteins: 3076
  matches: 3076
  proteomes: 2928
  taxa: 3744
  structures: 1
  alphafold_models: 1910
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022551
description: Bacillithiol (BSH) functions as a general thiol reductant, analogous to glutathione, in a
  wide range of bacterial species. Bacilliredoxins reduce those proteins that are modified by disulfide
  bond formation with BSH (S-bacillithiolation) [[cite:PUB00100073]]. This entry represents BrxC from
  Bacillus subtilis (formerly known as YtxJ) and similar bacterial proteins related to BSH. BrxC is a
  monothiol bacilliredoxin responsible for the removal of BSH from oxidized cytosolic proteins. It can
  also debacillithiolate the mixed disulfide form of the bacilliredoxin BrxB [[cite:PUB00055031],[cite:PUB00100075]].
  It has a similar fold to thioredoxin. The homologue in Deinococcus radiodurans, named AbxC, plays a
  role in the response to oxidative stress [[cite:PUB00100126]].