id: Pfam:PF11069
pfam_id: PF11069
name: Cilia- and flagella-associated protein 298
short_name: CFAP298
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11069
counters:
  proteins: 1901
  matches: 1910
  proteomes: 1452
  taxa: 4738
  structures: 1
  alphafold_models: 1654
  domain_architectures: 26
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021298
description: This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated
  protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role
  in cilia motility and polarization [[cite:PUB00089805]]. Primary ciliary dyskinesia (PCD) is caused
  when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities.
  Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26) [[cite:PUB00089729]].