id: Pfam:PF11081
pfam_id: PF11081
name: Adenovirus L4-33K/L4-22K
short_name: Adeno_L433K_22K
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11081
counters:
  proteins: 270
  matches: 285
  proteomes: 131
  taxa: 381
  structures: 0
  alphafold_models: 162
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021304
description: Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU)
  regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K [[cite:PUB00076403]].
  L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of
  mRNA production during the late phase of infection [[cite:PUB00076403]]. L4-33K is an alternative RNA
  splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses [[cite:PUB00076403],[cite:PUB00076401]].
  L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence
  within the packaging signal [[cite:PUB00076402]]. Additionally, L4-22K plays an important role in the
  temporal switch from the early to late phase of infection by regulating both early and late gene expression
  [[cite:PUB00076404],[cite:PUB00144935]].