id: Pfam:PF11145
pfam_id: PF11145
name: Transmembrane E3 ligase/DUF2921 transmembrane domain
short_name: DUF2921
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11145
counters:
  proteins: 4715
  matches: 5532
  proteomes: 1974
  taxa: 4518
  structures: 0
  alphafold_models: 3772
  domain_architectures: 106
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021319
description: This entry describes a domain of unknown function, which could adopt a similar fold to the
  SWEET-like (TM helices) domain. It was found in Transmembrane E3 ubiquitin-proteins and members of the
  DSC E3 ubiquitin ligase complex. It is predominant in fungi and plants, including the FLY1/2 proteins
  from Arabidopsis thaliana, the DSC complex protein from Schizosaccharomyces pombe, and TUL1 from Saccharomyces
  cerevisiae. This domain hasn't been functionally characterised yet but it is formed by seven alpha-helices
  [[cite:PUB00150892]].