id: Pfam:PF11160
pfam_id: PF11160
name: Hypervirulence associated proteins TUDOR domain
short_name: Hva1_TUDOR
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11160
counters:
  proteins: 5238
  matches: 5242
  proteomes: 4414
  taxa: 7010
  structures: 1
  alphafold_models: 3515
  domain_architectures: 48
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021331
description: Family members include Cryptococcus neoformans HVA1 (hypervirulence-associated protein 1)
  whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that
  when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1
  protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity
  with Tudor domains [[cite:PUB00091033]].