id: Pfam:PF11195
pfam_id: PF11195
name: Thoeris anti-defense 2-like domain
short_name: Tad2-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11195
counters:
  proteins: 1068
  matches: 1072
  proteomes: 882
  taxa: 1758
  structures: 14
  alphafold_models: 607
  domain_architectures: 9
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021361
description: This entry represents Thoeris anti-defense 2 from Bacillus phage SP01 (Tad2) and similar
  sequences from tailed bacteriophages and bacterial prophages. Tad2 is an anti-defence protein that counteracts
  the host Thoeris antiviral defence system. It sequesters the immune signalling molecules produced by
  Thoeris TIR-domain proteins in response to phage infection [[cite:PUB00153732]]. This entry also includes
  AcrIIA7 Cas9 inhibitor protein gene.