id: Pfam:PF11208
pfam_id: PF11208
name: Protein of unknown function (DUF2992)
short_name: DUF2992
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11208
counters:
  proteins: 936
  matches: 937
  proteomes: 873
  taxa: 1561
  structures: 0
  alphafold_models: 585
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR016787
description: This bacterial family of proteins has no known function. However, the cis-regulatory yjdF
  motif, just upstream from the gene encoding the proteins for this family, is a small non-coding RNA,
  Rfam:RF01764. The yjdF motif is found in many Firmicutes, including Bacillus subtilis. In most cases,
  it resides in potential 5' UTRs of homologues of the yjdF gene whose function is unknown. However, in
  Streptococcus thermophilus, a yjdF RNA motif is associated with an operon whose protein products synthesise
  nicotinamide adenine dinucleotide (NAD+). Also, the S. thermophilus yjdF RNA lacks typical yjdF motif
  consensus features downstream of and including the P4 stem. Thus, if yjdF RNAs are riboswitch aptamers,
  the S. thermophilus RNAs might sense a distinct compound that structurally resembles the ligand bound
  by other yjdF RNAs. On the ohter hand, perhaps these RNAs have an alternative solution forming a similar
  binding site, as is observed with some SAM riboswitches [[cite:PUB00109804]].