id: Pfam:PF11223
pfam_id: PF11223
name: SPP41, DUF3020
short_name: DUF3020
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11223
counters:
  proteins: 427
  matches: 432
  proteomes: 253
  taxa: 580
  structures: 0
  alphafold_models: 293
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021386
description: This domain is found in the conserved fungal proteins SPP41 (suppressor of PrP4, there are
  four members, 1 to 4). In S. cerevisiae it is conserved towards the C-terminus of HMG domains. The function
  is not known. However, it has been shown that SPP41 is involved in negative regulation of expression
  of spliceosome components PRP4 and PRP3 and that it relocalizes to the cytosol in response to hypoxia
  [[cite:PUB00098543],[cite:PUB00098542]].