id: Pfam:PF11250
pfam_id: PF11250
name: Fantastic Four meristem regulator
short_name: FAF
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11250
counters:
  proteins: 4362
  matches: 4370
  proteomes: 373
  taxa: 1017
  structures: 0
  alphafold_models: 3553
  domain_architectures: 51
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046431
description: FAF is a family of plant proteins that regulate the size of the shoot meristem by modulating
  the CLV3-WUS feedback loop. The proteins are expressed in the centre of the shoot meristem, overlapping
  with the site of WUS - the homeodomain transcription factor WUSCHEL- expression. FAF proteins are capable
  of modulating shoot growth by repressing WUS in the organising centre of the shoot meristem. The ability
  of plants to form new organs throughout their life cycle requires tight control of the meristems to
  avoid unregulated growth. Plants have evolved an elaborate genetic network that controls meristem size
  and maintenance. WUS and the CLAVATA (CLV) ligand-receptor system are at the core of the network that
  regulates the size of the stem cell population in the shoot meristem.