id: Pfam:PF11306
pfam_id: PF11306
name: Protein of unknown function (DUF3108)
short_name: DUF3108
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11306
counters:
  proteins: 8047
  matches: 8049
  proteomes: 6575
  taxa: 9208
  structures: 0
  alphafold_models: 5141
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021457
description: This is a bacterial family of putative lipoproteins. The structure for [swissprot:Q64U78],
  PDB:3fzx, the first structural template for this large family including several homologues in the human
  gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a
  small-scale porin (such as FepA). [swissprot:Q64U78] is a putative exported protein, and this fold is
  of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA|QNQDC, and a Phobius
  server prediction of non-cytoplasmic localisation for amino acids 21-236. The possibility of it being
  a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside
  the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially
  interesting. These two residues are also conserved in Dali hit PDB:2in5, a hypothetical lipoprotein
  classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded
  into a deformed beta-barrel) despite large structural differences between the two structures, suggesting
  similarity in function.