id: Pfam:PF11307
pfam_id: PF11307
name: Rv0495c-like
short_name: Rv0495c
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11307
counters:
  proteins: 4347
  matches: 4353
  proteomes: 4310
  taxa: 5507
  structures: 0
  alphafold_models: 2666
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021458
description: This entry, previously known as DUF3109, represents a bacterial family of probable redox
  regulatory proteins. A member of this family, Rv0495c, from Mycobacterium tuberculosis is essential
  for maintaining intracellular redox homeostasis [[cite:PUB00161582]]. Deletion of the Rv0495c gene (delta
  Rv0495c) results in increased levels of reactive oxygen species and a higher NAD+/NADH ratio, leading
  to a highly oxidised intracellular state [[cite:PUB00161582]]. Despite showing a growth defect in macrophages,
  the absence of Rv0495c increases M. tuberculosis pathogenicity in vivo, enhancing the bacterium's ability
  to proliferate inside the host.