id: Pfam:PF11330
pfam_id: PF11330
name: C-Terminal of 30K viral movement proteins
short_name: 30K_MP_C_Ter
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11330
counters:
  proteins: 4
  matches: 4
  proteomes: 2
  taxa: 15
  structures: 0
  alphafold_models: 1
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021479
description: This entry represents the C-terminal region found in viral movement proteins (MP) of the
  30K type. This region has been suggested to be conserved in secondary structure in Ophioviruses Mps.
  It contains two parts, (i) a long segment with the potential to form an alpha-helix (alphaB), rich in
  charged residues, and (ii) a region highly variable in sequence downstream of alphaB. The C-terminal
  region corresponds to a protease domain which contains a strictly conserved DTG tripeptide also found
  in related aspartic retroviral proteases. This protease is required for autocleavage of the Movement
  Protein of ophioviruses in an N-terminal part that supports movement of viral particles through the
  plant, and this C-terminal part which retains protease activity [[cite:PUB00097831]]. Mutations in the
  aspartate residue in the core domain [pfam:PF17644] had an impact on cell to cell movement [[cite:PUB00091032]].