id: Pfam:PF11331
pfam_id: PF11331
name: EDR4 zinc-ribbon domain
short_name: Zn_ribbon_12
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11331
counters:
  proteins: 2560
  matches: 2562
  proteomes: 375
  taxa: 1026
  structures: 0
  alphafold_models: 2050
  domain_architectures: 34
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021480
description: This zinc beta ribbon domain is found in Protein ENHANCED DISEASE RESISTANCE 4 (EDR4) and
  related plant proteins. EDR4 mainly localizes to the plasma membrane and endosomal compartments. It
  plays a negative role in resistance to powdery mildew and this requires salicylic acid signaling [[cite:PUB00090747]].
  In Arabidopsis, EDR4 associates with CLATHRIN HEAVY CHAIN2 (CHC2) and modulates plant immunity by regulating
  the relocation of EDR1 [[cite:PUB00090747]].